Updated October 29, 2026.

Not part of the Oct 28 HHS policy. Compounded PT-141 is not Vyleesi, is not a generic, and is not FDA-approved.

What is PT-141?

PT-141 is the research name for bremelanotide, a peptide that works on melanocortin receptors in the brain.

Unlike many sexual health medications, it doesn't work mainly on blood flow. It acts on pathways in the brain involved in desire.

What the research is looking at

Bremelanotide has been studied in two large clinical trials of more than 1,200 premenopausal women with low sexual desire.

In those trials, women who used it reported more desire and less distress about low desire than women on a placebo. It did not increase the number of satisfying sexual events.

Research in men and in postmenopausal women is smaller and earlier.

Who it may be for

Adults who are bothered by a drop in sexual desire often ask about PT-141.

Our provider will talk with you about whether it fits your goals and health history.

Regulatory status

Bremelanotide is the active ingredient in Vyleesi, a brand-name drug FDA approved in 2019 for one specific use: premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD).

Vyleesi is not approved for men or for women after menopause.

Compounded PT-141 is not Vyleesi, is not a generic version of it, and is not FDA-approved. FDA has not reviewed compounded PT-141 for safety, effectiveness or quality.

PT-141 is not part of the October 28, 2026 HHS peptide policy. Its compounding status falls under general federal and state compounding rules, which may change.

Read the full FDA update

Safety and side effects

In the Vyleesi trials, the most common side effects were:

  • Nausea (about 4 in 10 women), most often after the first dose
  • Flushing
  • Redness or soreness where it's given
  • Headache
  • Vomiting

It can also cause a short-term rise in blood pressure, and darkening of the skin in some people, especially with frequent use.

PT-141 is not right for you if:

  • You have high blood pressure that isn't controlled, or known heart disease.
  • You're pregnant, breastfeeding or trying to conceive.
  • You're under 18.
  • You take naltrexone by mouth.

Our provider will review your health history and medications before prescribing.

How it works at Optimize Hormone

Optimize Hormone offers these prescription peptides from an FDA-inspected 503(a) pharmacy in the US, with full testing reports, delivered directly to your home.

Our approach to peptide therapy is personalized and provider-guided, designed to support recovery, performance, longevity and overall wellness.

  • Bloodwork membership not required for peptides.
  • Complete your online intake, or book a free consultation if you'd like to talk it through first.
  • Our provider reviews your health history and goals and determines whether PT-141 is appropriate for you.
  • If prescribed, your medication ships to your door with all necessary supplies, plus personalized dosing and instructions from your licensed provider.

How it's delivered

Your prescription arrives pre-mixed and ready to use, with all the supplies you need.

Our provider will walk you through how and when to use it.

Monthly membership: $125/month

Book your free consultation

Start your intake

Common questions

How is PT-141 different from ED medications?

Medications for erectile dysfunction work mainly on blood flow. PT-141 works on pathways in the brain involved in desire.

Is this the same as Vyleesi?

No. It's the same active ingredient, but compounded PT-141 is a different product and is not FDA-approved.

How often can it be used?

PT-141 is used as needed, not every day. Our provider will give you personalized dosing and limits, including how much time to leave between doses.

What if I get nausea?

Nausea is common, especially the first time, and often improves with later doses. Let our provider know if it's severe or doesn't go away.

How to get started

1. Complete the short online intake.

2. Or book a free consultation if you'd like to talk it through first.

3. Our provider reviews your answers and lets you know whether PT-141 is a fit for you.

More peptides

Educational information only, not medical advice. Compounded medications are not FDA-approved, which means FDA does not review their safety, effectiveness or quality before they are dispensed. Our provider determines whether any medication is appropriate for you. Regulatory information is current as of October 29, 2026 and may change. Prescriptions are filled by a state-licensed 503(a) compounding pharmacy in the US.